Uricase

Définitions de « uricase »

Uricase - Nom commun

• Enzyme catalysant la transformation de l'acide urique en allantoïne, participant ainsi à la dégradation des purines. Présente chez certains animaux comme les oiseaux, mais absente chez la plupart des mammifères.

  Nous pouvons admettre que si l'uricase, l'allantoïnase, l'allantoïcase et l'uréase existent, le catabolisme purique pourra être poussé jusqu'à la production d'ammoniaque à partir de l'azote du noyau purique.

Évolution historique de l’usage du mot « uricase » depuis 1800

Citations contenant le mot « uricase »

• (Medical Xpress)—Apes, including humans, lack an enzyme called uricase that breaks down uric acid. Because we lack uricase, we are predisposed to developing gout. After reconstructing ancient versions of the enzyme found in other mammals, Eric Gaucher of the Georgia Institute of Technology and his colleagues have concluded that apes lost the ability to produce uricase so they could better convert fructose, fruit sugar, to fat for survival when fruit was scarce. The research appears in the Proceedings of the National Academy of Sciences.

• Protalix has partnered with Chiesi Farmaceutici S.p.A. for the global development and commercialization of Elfabrio. Protalix's development pipeline consists of proprietary versions of recombinant therapeutic proteins that target established pharmaceutical markets, including the following product candidates: PRX–115, a plant cell-expressed recombinant PEGylated uricase for the treatment of severe gout; PRX–119, a plant cell-expressed long action DNase I for the treatment of NETs-related diseases; and others.

Traductions du mot « uricase »

Sources et ressources complémentaires

• Définitions du TLFi
• Définitions du Wiktionnaire