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• “First line treatment [of autoimmune hepatitis] consists of the combination of azathioprine with prednisolone, and these recommendations are based on clinical trials executed in the ’60s and ’70s,” Romée JALM Snijders, MD, a PhD candidate in the department of gastroenterology and hepatology at Radboud University Medical Center in the Netherlands, said. “Mycophenolate mofetil (MMF) has emerged as an alternative option to azathioprine. ... MMF has shown particularly favorable outcomes in patients intolerant to azathioprine and prospective studies have shown good results and promising results regarding the efficacy and safety of MMF.”

• Since the introduction of azidothymidine in 1987 there have been major improvements in the treatment of HIV. In a recently published study, Forsythe and colleagues demonstrate that the advent of antiretroviral therapy (ART) in the mid 1990s has yielded significant achievements in global public health. Between 1995 and 2015, 9.5 million deaths have been averted worldwide, and global economic benefits are estimated at over $1 trillion.

• POST local government elections bacchanal continued on Thursday when the Elections and Boundaries Commission (EBC) said the PNM won the Arima Northeast district which falls under the Arima Borough Corporation.

• In Belgium, a person has requested to be debaptized and to have their name erased from the Catholic Church's baptismal register. Such requests for debaptism are on the rise. Pictured here are the bell tower of Saint Nicholas Church and Saint Bavo's Cathedral in the city of Ghent, on December 11, 2023. (Photo by VINCENT ISORE / IP3 PRESS/MAXPPP)

• Just learnt about Sir Ewan Forbes, a trans baronet who was born in 1912 and passed away in 1991. I hadn’t heard of him before, but a customer told me all about him when buying Zoë Playdon’s book on him. I know what I’m buying next! pic.twitter.com/mcwlwZUM7k

• As organized crime advances in the Amazon basin in search of land to plant coca, riverine routes for narcotrafficking, and alluvial gold, the rainforest and the security of the region’s communities and defenders are threatened, international nongovernmental organization (NGO) Crisis Group said in a recent report.

• The Washington Department of Fish and Wildlife says it detected pneumonia in the Northern Hells Canyon bighorn sheep population in December of 2023.

• Bernoulli trials, and binomial distribution (from Unit 14: Statistics and Probability)

• Ces experts nutritionnistes de l'Universitat Rovira i Virgili (Catalogne) ne sont pas contre les sushis mais à condition de limiter les quantités de thon : leur analyse des concentrations de différents composés toxiques dans ces aliments suggère en effet de bien choisir ses makis, nigiris ou sashimi, notamment en raison de niveaux plus élevés de mercure et de méthylmercure dans les sushis contenant du thon, liés à la bioaccumulation et à la bioamplification de ce métal. Les chercheurs évaluent également, dans la revue Food and Chemical Toxicology, le risque lié à leur consommation, chez les nourrissons, les adolescents et les adultes.

• Libourne – 27 septembre 2021 – Fermentalg (Euronext – FALG), acteur majeur français des microalgues, est heureux d'annoncer la mise en service par CarbonWorks, sa filiale détenue à parts égales avec le groupe Suez, du premier démonstrateur industriel de sa technologie de capture et de bioconversion du CO2 (Carbon Capture and Utilization ou CCU) par photosynthèse algale.

• Selon les Centers for Disease Control and Prevention (CDC) des États-Unis, qui forment ensemble la principale agence fédérale de santé publique, si une attaque bioterroriste devait se produire, elle impliquerait très probablement la bactérie responsable de l’anthrax, comme en 2001. Celle-ci a d’ailleurs été étudiée par de nombreux pays à des fins militaires, et ce, depuis la Seconde Guerre mondiale.

• Droser, M. L. & Bottjer, D. J. Trends in depth and extent of bioturbation in Cambrian carbonate marine environments, western United States. Geology 16, 233–236 (1988).

• But did that bioturbation help or hinder the expansion of complex animal life? A new Yale study, published in the journal Earth and Planetary Science Letters, found that seabed burrowers were very helpful indeed.

• The synthesis of these planar pentadentate compounds was fairly straight-forward involving a ring expansion with alkynes or allenes with various substituents. The first product, resulting in phenyl substituents on the six-membered ring and the three-member ring was made with 3-ethynylthiophene and silver borohydride at room temperature. This product, as well as the ones with cyclohexane, cyclopropane, and thiophene substituents was characterized with NMR, high-resolution mass spectrometry, and elemental analysis, all of which confirmed a pentagonal bipyramidal structure and delocalized Os-C bonds.

• The Ethiopian birr crashed as the country neared its first coupon miss as the economy faces numerous internal and external shocks. In a statement on Friday, the government warned that it was not able to pay the coupon, worth about $33 million. 

• Sodium bisulfite causes irritation to eyes, skin and mucous membranes if inhaled, ingested or comes in contact with eyes or skin, police officials said.

• Ms. Ma had been running a flower shop at Rua da Emenda for over 20 years, specializing in orchids, chrysanthemums, and narcissus. She told Xinhua that orchids were popular in Macao due to their long blooming period. "We start selling flowers for the Spring Festival in January, and it goes on for about a month."

• A member of the public discovered two malnourished Pitbull crossbreed pups abandoned at a bog in Donadea, County Kildare, and turned them over to the charity.

• A safety bollard was damaged and there were no injuries.

• Kim's Russia visit and show of bonhomie with President Vladimir Putin has heightened Western concerns that Moscow and Pyongyang may defy sanctions and engage in arms negotiations.

• Konrad said the most troubling finding in the study was the lack of either a trickle-down or a bottom-up effect linking lower and middle management to the top management teams.

• The project’s national researcher in Brazil and Director for Institutional Cooperation, International and Innovation in the Lula administration, Dr Dalila Andrade Oliviera, next reiterated the sentiments expressed by Heleno, emphasising that the learning circles project allows teachers and unions to shape learning and development from the bottom-up by working “with teachers in the classroom.”

• A delicious selection of breakfast foods including Eggs Benedict, Sweet Bread Pudding, Sausage or Ham Biscuits, and a Berry Delight Torte were served.

• According to the researchers, if you divide the distance from the bregma to the inion by the distance from the nasal junction to the bregma, and then divide the size of the nasioniac arc by the bregma-inion distance, the two numbers form a ratio of roughly 1.6.

• For the new study, Tamargo and colleague Dr Jonathan A Pindrik, his co-author, examined the head CAT scans of 100 patients. Indeed, they found, the two sub-arcs on either side of the bregma are in a ratio that approximates the golden ratio.

• Russian investigators are currently probing a case related to the biggest attempted bribe in recorded Russian history. FSB officers and officials from the Investigative Committee are said to have fabricated a murder case then tried to use it to extort 15 billion rubles ($200 million) from the alleged suspects, the owners of one of the country’s leading electronics trading companies. The brains behind the plot were the son of an old friend of Vladimir Putin and the business partner of Prime Minister Mikhail Mishustin’s son-in-law.

• The bureau said the actual amount incurred was around $170,000, and Chan used the money claimed to bribe Chiew.

• “The ED investigation has revealed that M/s NKG Infrastructure Ltd obtained the bid by submitting forged/fake/false documents. Arora was aware of the fact that the company does not meet the technical eligibility and he received a bribe amount both in cash and in his bank accounts,” the spokesperson alleged.

• Deux patients atteins de bronchectasie ont vu leur état de santé s’améliorer grâce à une thérapie novatrice, selon les résultats d’une étude publiée dans la revue médicale American Journal of Respiratory and Critical Care Medicine. La plasmaphérèse, sorte de dialyse du sang a permis de nettoyer leur sang d’un anticorps responsable de leur infection chronique.

• A 41-year-old man previously diagnosed with asthma presented with an influenza-like illness and breathlessness. He was treated for moderate-to-severe COVID-19 and exacerbation of asthma. CT pulmonary angiography (CTPA) revealed asymmetrical peribronchovascular ground-glass infiltrates consistent with COVID-19 and right main bronchial wall thickening with high-density material thought to be consistent with mucous impaction (figure 1A). He was discharged 8 days after admission.

• During the procedure, a doctor passes the bronchoscope into a person’s airways to help diagnose certain respiratory conditions and clear blockages.

• In the Beatles Anthology book, Paul writes of going to Goodison with his Uncles, and mentions the bugler playing "Over the mountains, over the sea" when a shot went well over the bar.

• Then they applied the FastGC-PTR-MS to detect the isomers of butanol in latex paint, and found that the headspace of brand D latex paint mainly contained tert-butanol (4.41 ppmv), n-butanol, acetaldehyde, methanol, and acetone. The concentration of tert-butanol was much less than the maximum allowable concentration in the workplace (100 ppmv).

• Son implant Agili-C, composé d’une forme de carbonite calcique appelée aragonite, a été qualifié de dispositif révolutionnaire par la Food and Drug Administration des États-Unis en 2020, puis a été approuvé en 2022 pour les lésions de surface des articulations arthritiques et non arthritiques du genou. En juillet, CartiHeal a annoncé sa première implantation commerciale d’Agili-C aux États-Unis.

• New Baltimore Ravens defensive coordinator Zach Orr might be a first-time play caller and the league's second-youngest coordinator, but he's been thinking about being in this position for many years now.

• A caller stated that a man was acting erratically while attempting to steal his van, then the call ended. Minutes later, the caller again dialed 911 to report that a struggle ensued and that the caller was now in the back of the van that had just been stolen by the suspect.

• The researchers found that capacitance generally increased linearly with length between 10 and 60 cm, after which gains in capacitance slowed significantly as length increased. The results were also influenced by the frequency of the electricity—or the rate at which the electrical current oscillates.

• Higher and lower capacitance values both have their own pros and cons: you’ll need to decide what value best balances them for your intended application. To that end, let’s look briefly at both sets of advantages.

• US-based captable management firm Carta has rolled out its services in the Middle East, onboarding over 100 venture capitalists and startups from the region on its platform, including names such as Global Ventures, BECO Capital, Foodics, and Kitopi.

• Infinited’s technology turns any cellulose-rich raw material, including discarded textiles, cardboard or rice or wheat straw, into cellulose carbamate fibres, high-quality textile fibres with the look and feel of cotton.

• MTM Critical Metals Limited (ASX:MTM) (MTM or the Company) has intercepted further significant TREO mineralisation in diamond drilling from holes POM-23-09, POM-23-11, POM-23-12 and POM- 23-13 at its Pomme REE-Niobium carbonatite project located in Québec, Canada.

• These emulsions are termed switch-oil-phase (SWOP) emulsions and are formed by a combination of polyglyceryl-2 dipolyhydroxystearate as a w/o emulsifier, a mixture of lauryl glucoside and sodium lauryl glucose carboxylate as anionic surfactants, and sodium polyacrylate as a polymeric stabiliser.