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Citations sur le AND

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• AM Resources Corporation, a dynamic junior mining company focused on the exploration and development of high-potential pegmatite deposits, has announced the acquisition of a significant land package totalling 1500 km2 through map staking in Austria.

• Pfizer has announced the US Food and Drug Administration’s approval of Penbraya, the first and only pentavalent vaccine for coverage against the most common serogroups causing meningococcal disease in people aged ten to 25 years.

• Pillai, B. et al. Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis. J. Mol. Biol. 365, 343–361 (2007).

• Ontario's health care spending was the lowest in Canada per capita and below the average of other provinces in the 2022-2023 fiscal year, according to a new report by a government watchdog.

• You’ve finished a workout, so you’re hot and drenched with perspiration – but soon you begin to feel cool again. Later, it’s a sweltering summer evening and you’re finding it hard to sleep, so you kick off the covers.

• As shared by Patently Apple, the tech giant has submitted an application with the US Patent and Trademark Office to help measure a user's perspiration level via electrodes beneath the device.

• Researchers achieve high selectivity and permeability in a pervaporation setup which could replace energy-intensive distillation processes in chemical industries

• Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self–non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self.

• (Francisco Kjolseth | The Salt Lake Tribune) Great Salt Lake advocate and activist author Terry Tempest Williams, center, joins environmental groups, scientists and community members on the steps of the Utah Capitol to petition for a threatened species listing of Wilson's phalarope on Thursday, March 28, 2024, and by extension the health of the Great Salt Lake.

• The schematic representation of the proposed virtual screening approach. The MAOs ligands selected from the ChEMBL database are docked, and the pharmacophore hypotheses of the best docking molecules are generated. In parallel, the fingerprints and descriptors of the docked compounds are applied to train machine learning models, allowing the prediction of activity values and docking scores. The pharmacophores and binding models are used to identify the most promising compounds from the ZINC database.

• Zhou, Y., Di, B. & Niu, M.-M. Structure-based pharmacophore design and virtual screening for novel tubulin inhibitors with potential anticancer activity. Molecules 24(17), 3181 (2019).

• Les auteurs de l'étude ont pour cela calculé l'âge phénotypique (l'âge corporel lié à l'état de santé) et l'accélération de l'âge phénotypique (la différence entre l'âge réel et l'âge phénotypique) de plus de 6.500 adultes ayant participé à la National Health and Nutrition Examination Survey (NHANES), un programme de recherche mené par les Centers for Disease Control and Prevention (CDC) aux Etats-Unis, entre 2015 et 2018. Présentés par l'American Heart Association, ces travaux montrent qu'une bonne santé cardiovasculaire peut permettre de freiner le vieillissement biologique, et que le fameux "Life's Essential 8" peut amplement y contribuer.

• Groups of randomly oriented, sprays of Al-tobermorite appear to postdate analcime and phillipsite (Fig. 6b, RS-17, d, RS-3, e, RS-14). Gypsum crystals (Fig. 6f, RS-9) have platy to coarse prismatic forms in matrix pores, with larger crystals commonly below water level.

• Rabelais et l’énigme philologique de la graine d’alkermès /Rabelais and the philological mystery of kermes dye   111

• It was Lavoisier’s obsession with weighing the reactants and products of a reaction that really turned the phlogiston theory on its head. When a substance burned in air, he found, it increased in mass rather than decreased as phlogiston theory predicted. Lavoisier coined the term ’oxygen’ to describe the part of the air that combines with a combustible substance when it burns. 

• The study finds that increasing demand for ammonium phosphatides in the chocolate and confectionery will continue to drive gains in 2019 and beyond. Confectioners and chocolate manufacturers are investing in sustainable emulsifiers, and these evolutions have rubbed off on ammonium phosphatide providers as well.

• An efficient reaction between triphenylphosphine or triphenyl phosphite and 2-oxoindoline-3-ylidene derivatives in the presence of acetylenic esters leads to functionalized 2-oxoindoline-3-ylidene containing phosphorus ylieds or phosphonate esters. All compounds obtained in these reactions are stable and have good yields.

• SI Group, a global developer and manufacturer of performance additives, process solutions, pharmaceuticals, and chemical intermediates, announced that the U.S. Food & Drug Administration (FDA) has granted Food Contact Notification (FCN) 2326 for phosphite antioxidants WESTON 705 and WESTON 705T. The FCN extends the use of these phosphite antioxidants to polyethylene terephthalate (PET) polymers.

• Nucleic acid chemistry has a long history. Indeed, Todd and coworkers initiated, in the early 1950s, an extensive study of nucleoside polyphosphates (e.g., ADP, ATP), which later led Gilham and Khorana to implement the use of carbodiimides or arenesulfonyl halides to facilitate esterification of P(V) oxidation level deoxyribonucleoside phosphomonoesters to their corresponding phosphodiester derivatives 2 and 3 (Scheme 1).

• Szendroedi, J. et al. Skeletal muscle phosphodiester content relates to body mass and glycemic control. PLoS One. 6, e21846 (2011).