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• For months now, legal experts have been translating and outlining the necessary steps for industry to take in preparation for MOCRA's implementation. These range from creating an adverse event reporting system, and maintaining current and complete safety substantiation records, to ensuring facilities are registered with the FDA and more; see our full checklist, here.

• In a filing with Bursa Malaysia, Econpile said the job will entail undertaking the construction and completion of site clearing, earthworks, substructure and structure works for a five-storey basement car park, including the floor slab of lower ground 2 at the building.

• The subthalamus acts as a control center for the peripheral nervous system, which encompasses all your nerves. It’s also responsible for stimulating the thalamus, somatic motor function, and assisting with vision.

• The effect was discovered by Xiaobing Zhang and Anthony van den Pol of the Yale School of Medicine in Connecticut, whose research has focused on the zona incerta (ZI), a horizontally elongated section of grey matter located in the brain’s subthalamus region.

• Potapov AG, Shundrina IK. Effect of aliphatic diols and dicarboxylic acids on the properties of ethylene succinate copolyesters. Polym Sci Ser A 2019;61:544–54.

• Interest in the case was renewed after an analysis of Franco's tissue samples revealed the presence of succinylcholine and morphine, neither of which were ordered by her doctors, St. Louis Public Radio reported.

• There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest and death after the administration of succinylcholine to apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular dystrophy.

• "We assessed sugar preferences and intestinal sucrase activity of Australian specialist and generalist nectarivores for comparison with published data from other nectarivorous bird species and compared laboratory data with foraging records from the wild," Ms Napier says.

• To support this growth, Materne realized it needed to grow its supplier network, adding layers of continuity to support new products and protect against supply chain disruptions.

• Nexans awards the status of preferred supplier only to suppliers with a good CSR performance, among other strengths, and supports suppliers that improve their CSR performances in a continuous and sustainable way. Nexans reserves the right to delist a supplier that does not comply with the CSR principles.

• Beijing WeLion New Energy Technology, a supplier of semi-solid-state batteries to Nio (NYSE: NIO), and an electric vehicle (EV) unit of Anhui Jianghuai Automobile Group (JAC) have reached an agreement to jointly develop long-range cars.

• • Mr Ong's lawyers will argue that Section 377A "violates human dignity" and that sexual orientation "is unchangeable or suppressible at unacceptable personal cost".

• In the 1980s, water along the coast was sealed off in supralittoral ponds for commercial shrimp farming. In 1994, a government order, passed without discussion, declared the entire coast open for shrimp farming. This brute-force displacement of coastal agriculture by commercial farming not only did away with agricultural communities’ basic right to work, it also cost them their rights to water, marshes, forests and land. Virtually overnight, work that for centuries had been guaranteed for a multigenerational multitude was now held by a handful of people employed in shrimp farms.

• Pour expliquer cette surmédicalisation des enfants, Céline Lamy montre du doigt la manière dont est utilisé le Diagnostic and Statistical Manual of Mental Disorders (DSM), un ouvrage qui répertorie tous les troubles psychiatriques, et qui est largement utilisé au Québec. Lors de sa publication en 1952, on y recensait environ 60 pathologies différentes. Chaque nouvelle version contient de nouveaux troubles — l’homosexualité y avait d’ailleurs été introduite en 1968, avant d’être retirée quelques années plus tard. Pour chaque trouble, on établit un nombre de critères auquel doit répondre le patient pour qu’on puisse établir un diagnostic.

• The Olympic dream has been one that the Numa family have always aspired to and its every parents dream to see their children excel in a vocation they choose to be surpassable in.

• Interdigitation, midpalatal suture density ratio, and density of the sutural area relative to hard tissues may not be useful indicators of midpalatal suture maturation.

• Le Figaro newspaper reported that the government wanted children to wear a white or grey polo shirt, blue sweater and grey pants. This was confirmed to AFP by a government source. Local authorities will, with some conditions, be able to choose their own uniforms, but the government has proposed its colors. According to Le Figaro, half the cost of each child's uniform will come from public money.

• This category includes both the initial welcome bonus offered by a sweepstakes casino and the promotions it offers to existing players. We carefully evaluate each sweepstake casino’s bonuses and promotions to find the very best for our readers. 

• This free to play sweepstake generator has been created in association with Racing Welfare who work to support current and retired racing staff, and their families through professional help and practical guidance.

• As of February 2021, the proven and probable reserves at the Tugaske project were estimated at 34.93Mt of sylvinite and 14.53Mt muriate of potash (MOP) with a combined grade of 42.26% potassium chloride (KCl).

• When you think of a mine, you may picture grimy, black soot and sickening dust. But the walls of Berezniki, Russia's sylvinite mine hold layers of red, blue and orange. The rainbow walls are created by potassium-rich sylvinite deposits that formed millions of years ago, when ancient underground oceans dried up, leaving beind rock and salts. 

• Interestingly, strawberry inflorescences combine two branching systems – a monopodial primary axis and sympodial lateral branches – and are botanically known as thyrses. The development of thyrse architecture has not been previously explored in any other plant.

• Histological findings were reported as follows: "Direct potassium hydroxide (KOH) microscopic examination from skin scrapings revealed branched brown hyphae with light brown septa. A fungal culture on Sabouraud's agar media produced wet, medium brown, yeast-like colonies, the surface of which later became black and shiny. A slide culture disclosed light brown, elliptic or peanut-shaped conidia comprised of one to two ampullaceous cells. Scanning electron microscopic examination of the conidia showed both annellation [sic] conidia with lunate bud scars and sympodial conidiogenesis."

• Cotton bolls were collected from the 10 mature plants of each experimental unit, and average boll weight was determined by dividing total seed cotton yield per plant to the total number of bolls. Number of sympodial branches per plant were calculated from 10 randomized selected plants of each experimental unit.

• Giuseppe was assigned to the Synchrocyclotron Division.  This was the first accelerator built at CERN and was operated from 1957 until 1990. Giuseppe set up a group and prepared the basic equipment for experiments that was used in 1958 for a successful search for pions decaying into an electron and a neutrino. This was a hot topic at the time and was the first experiment involving a CERN accelerator. "The news went all over the world overnight," recalls Giuseppe. Recently refurbished, the synchrocyclotron will soon become a permanent exhibit at CERN.

• This was reported to the entire world by the Pravda newspaper on 11 April 1957. The later date was due to the fact that the event took place only after the accelerator’s energy gradually raised since the commissioning day and exceeded the energy of 6,3 GeV of the then leading American synchrophasotron in Berkeley. “8,3 billion electronvolts reached!” the newspaper reported and thus announced that a record accelerator had been created in the Soviet Union.

• On the admission day, the patient was coughing repeatedly at home. After a vigorous cough he had a syncopal episode. Right after this, the patient was brought to the emergency department (ED) and admitted for syncope workup.

• A 23-year-old woman with past medical history of bipolar II disorder and a REM-specific seizure disorder that resolved at age 9 presented after a syncopal episode. The patient reported an initial sensation of lightheadedness while at work, which was followed by a syncopal episode with brief (1-2 min) loss of consciousness and a minor head injury.

• Here, we report using plaque unit forming titration, qPCR, immunofluorescence, and transmission electron microscopy that these isolates infect cells derived from a malignant human glioblastoma (U251 line). However, DENV3 MG-20 infected these cells with syncytium formation and cell death, while DENV3 PV_BR infected cells without syncytium formation or any other cytopathic effect (CPE) evidenced by optical microscopy. These results emphasize the difference in biological characteristics of these isolates, which could be a critical component in the interaction with the host cell and the development of severe dengue.

• Immunofluorescence studies (S protein-specific antibodies) from each syncytium indicate a very high infection level. We could not find any syncytial cells in mildly infected patients. However, identical (neutrophils or type 2 pneumocytes) and heterotypic (neutrophils-monocytes) plasma membrane initial fusion (indicating initiation of fusion) was observed under TEM in moderately infected patients. Fully matured large-size (20–100 μm) syncytial cells were found in severe acute respiratory distress syndrome (ARDS-like) patients of neutrophils, monocytes, and macrophage origin under SEM.

• Kat Schroeder, a PhD student from the Department of Biology at the University of New Mexico, described the fusion of certain vertebrae into the synsacrum and pygostyle as one of the most significant evolutionary adaptations in birds.

• Charles Darwin collected this syntype male specimen of Docemina crassipes in Tierra del Fuego, an archipelago at the southernmost tip of South America, during his voyage onboard the H.M.S. Beagle (1832 to 1836). The species was described in 1918 by the English entomologist George Charles Champion, in the journal Annals and Magazine of Natural History.

• Representative Dave Lislegard (DFL-Aurora) and Senator Grant Hauschild (DFL-Hermantown) called on Republicans to retract their proposal to send taconite tax dollars to non-Iron Range communities of Cromwell, Moose Lake, and Willow River.

• WASHINGTON — The state’s Indian tribes are panning the Environmental Protection Agency for failing to impose tougher restrictions on mercury emissions from taconite operations, saying they would fail to prevent continued land and water contamination.

• SEATTLE — A graffiti tagger who was accused of causing hundreds of thousands of dollars in damage to public and private property in Seattle has been ordered to spend 80 hours cleaning up graffiti in the city, according to a plea agreement.

• The new facility will serve a large number of clients and allow multiple mines to send tailings for processing and testing.

• EnviroGold Global Ltd, the technology company seeking to enable the global mining industry to monetise valuable metals contained in mine waste and tailings including gold, silver, copper, zinc, and nickel, has provided an update on its plans to demonstrate and commercialise its proprietary leaching technology – the NVRO Clean Leach Process. EnviroGold has selected a manufacturer to construct the processing unit that will be used to demonstrate the NVRO Clean Leach Process to several potential customers, including major global mining companies.

• New research out of ETH Zurich suggests that certain features of the tailings dam at Vale’s Corrego do Feijao iron ore mine in Brumadinho, southeastern Brazil, may have been the cause of the burst that released 10 million cubic metres of liquefied tailings, destroyed neighbouring settlements, took a railway bridge with it and killed at least 270 people.

• Following the catastrophic dam collapse at Vale’s Corrego de Feijao mine in Brumadinho, the Global Industry Standard of Tailings Management (GISTM) was developed to enhance the safety and strengthen the governance of tailings facilities across the globe.

• The candidate aims are to design, manufacture, and study advanced photonic integrated waveguides and microresonators based on a thin-film periodically poled lithium tantalate nanowaveguide platform. The main focus will be the development of advanced nanofabrication technologies for optical waveguide fabrication with low optical loss and high optical nonlinearity to demonstrate breakthroughs in the efficiency and bandwidth of nonlinear optical amplification and frequency conversion. The research will be performed at the Department of Electronic Systems, NTNU, and supported by scientific partners in Switzerland and China.

• John McAdam had originally created the method of using crushed stone road surfaces, with the name of tarmacadam derived from him. But he was not able to create a surface where stones stuck together. Mr Hooley took what he saw and spent a year working on a method to replicate it elsewhere. By 1902 he had patented a process of adding slag to heated tar and breaking stones within the mixture to create a smooth, sold surface. He made Radcliffe Road in Nottingham the world’s first Tarmac road, covering five miles of it with his mixture.

• Holton, R. A. et al. First total synthesis of taxol .2. Completion of the C-Ring and D-Ring. J. Am. Chem. Soc. 116, 1599–1600 (1994).