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Citations sur le AND

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• From muscle contraction to nerve conduction, a wide range of physiological functions rely on ion channels, transmembrane proteins that shuttle charged species into and out of the cell. While these channels possess a well defined pore space through which ions travel, prolonged exposure to heat or certain ligands causes the pore to enlarge. Ion channels from the transient receptor potential (TRP) and  P2X families exhibit this pore dilation phenomenon, resulting in an increased flow of ions, loss of directionality in transport, and access by larger charged molecules. 

• There are two forms of isosorbide: mononitrate and dinitrate. Isosorbide mononitrate differs from isosorbide dinitrate in the way it’s metabolized by your liver. Isosorbide mononitrate doesn’t undergo a first pass of your liver and lasts many hours longer before it’s eliminated.

• In this work, we report new insights into the processes of serpentinization and carbonation of diopside in diopsidite from the Yushishan Nb–Ta deposit in the eastern part of the Altun Mountains, northwest China. Mineral assemblages and microstructures show obvious features of mineral alteration. Bulk-rock geochemistry and mineral composition reveal coupled serpentinization and carbonation of diopside. These results also allowed us to probe potential permanent carbon reservoirs over geological timescales.

• May S, Hornburg D, Schludi MH, Arzberger T, Rentzsch K, Schwenk BM, et al. C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol. 2014;128:485–503.

• Recent research has turned the spotlight on the molecular design and formation of dipeptide coacervates centered around a diphenylalanine (FF) core. Scientists are curious about how the variations in the functional groups of these peptides impact their self-association and phase behavior. Dipeptides with the FF motif have gained recognition for their ability to form nanofibrils and other nanostructures.

• Writer-Director Phoebe Nir on how her directorial debut Eco Village attracted an impressive cast and premiered at Rotterdam International Film Festival.

• In 2022, Riteish Deshmukh directed the Marathi hit “Ved,” starring himself and his wife Genelia, which became one of the highest-grossing Marathi films. The film was directed by Riteish, in his directorial debut, and produced by Genelia, both of whom also starred along with Jiya Shankar, marking her debut in Marathi films.

• The actress and director makes her feature-length directorial debut with the horror comedy starring Kathryn Newton and Cole Sprouse. She shared news of her involvement back in 2022 on Twitter, calling Lisa Frankenstein “the most bonkers, wonderful zombie script” she had ever read. 

• Experts have just started to question Prince Harry and Meghan Markle’s future, in light of the fact that they have “absolutely no discernable skill set.”

• The dispatcher would get it, look at it, dispatch it, timestamp the card and then put it in the slot with with the officer's call sign.

• HIGHER LEARNING: Debora Foerst, Cherokee High School principal, defended her disquisition successfully on Wednesday, March 21 and will have her doctorate in education (EdD) degree conferred upon her from Western Carolina University in May. (SCOTT MCKIE B.P./One Feather)

• Just a month before Election Day, Trump turned in the nastiest debate performance in modern political history. In one stunning exchange, he turned a grilling about his boorish behavior into a disquisition on former President Bill Clinton’s sexual history and his rival’s alleged role in discrediting his accusers. “I think it’s disgraceful, and I think [she] should be ashamed of herself,” Trump said.

• Johnson was a great dissembler and certainly an effective networker, and could present himself as all things to all men. Over time, he managed to wheedle his way into Roosevelt’s inner circle and was seen by the latter as a principled progressive. But to Johnson’s business backers he was the man who could win them lucrative contracts and seen as a man of the conservative right. He was not averse to concluding shady deals with his backers and small-time gangsters, even to the extent of actually buying votes with cash and employing dirty tricks to defeat his opponents.

• Jhajharia, D. & Singh, V. P. Trends in temperature, diurnal temperature range and sunshine duration in Northeast India. Int. J. Climatol. 31, 1353–1367 (2011).

• Our study provided a novel tool to explore the diurnal pattern of physical activity and to investigate its impact on health outcomes."

• Aims To report the baseline intraocular pressure (IOP) characteristics and its diurnal fluctuation in the Laser in Glaucoma and Ocular Hypertension China cohort.

• Juventus and France midfielder Paul Pogba has been provisionally suspended after a doping control detected elevated levels of testosterone, Italian anti-doping authorities (Nado) told AFP on Monday, September 11. After a nightmare season between injuries and a blackmail affair, the 30-year-old's dreams of bouncing back were shattered by the alleged doping offense after Juventus's 3-0 win at Udinese on August 20, during which he was an unused substitute.

• Among critical WADA requirements are “effective, intelligent, and proportionate” doping test distribution plans, sharing and maintaining training pool athletes’ lists, and timely prosecution of doping cases.

• The implementation of the FLANDERS dragline conversion brought about substantial improvements for a coal mine in Queensland operating multiple draglines. By replacing the outdated DC 8050 dragline’s power system with a safer AC power system, the mine experienced noteworthy enhancements in productivity, power efficiency, and energy savings.

• The water and drain cleaner have both been pulled from shelves due to production defects Pic: onebit / Boris Medvedev / Shutterstock