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• With information about the relationship between carbon dioxide, lycophyte characteristics, and relative carbon isotope abundance, the researchers estimated the CO2 content of the air in which 66 fossil lycophytes grew. The fossils were diverse, representing three lycophyte genera from 13 geological deposits at nine distinct localities.

• In ancient times, the purity of precious metals was gauged using a touchstone: a small tablet of dark fieldstone, slate or lyddite on whose finely grained surface soft metals such as gold left a visible trace. From its earliest known use by the Harappan civilisation of the Indus Valley, this simple test of authenticity travelled to Europe and beyond, its symbolism as well as its practical application intriguing philosophers of every epoch, from classical Greece to the modern era.

• As well as the obvious danger of bombs, many of the female munitions workers suffered illnesses which later proved fatal, caused by exposure to lyddite and amatol explosives.

• PRINCETON, N.J. - Bristol Myers Squibb (NYSE: BMY) a annoncé aujourd'hui que la Food and Drug Administration (FDA) américaine a accordé une autorisation accélérée à Breyanzi (lisocabtagene maraleucel ; liso-cel), une thérapie cellulaire CAR (chimeric antigen receptor) dirigée contre le CD19. Cette autorisation permet le traitement de patients adultes atteints de leucémie lymphocytaire chronique (LLC) ou de lymphome lymphocytaire de petite taille (SLL) en rechute ou réfractaire, ayant reçu au moins deux traitements antérieurs, dont un inhibiteur de la tyrosine kinase de Bruton (BTK) et un inhibiteur du lymphome à cellules B 2 (BCL-2).

• ORF3a blocked the retrieval of CI-M6PR from Rab7-positive endosomes to the TGN and, consequently, impaired the sorting of newly synthesized lysosomal hydrolases from the TGN. ORF3a expression and SARS-CoV-2 infection also impaired the fusion of Rab7-positive compartments with Arl8b and LAMP1-positive compartments that mediate virus egress from host cells. Taken together, our results suggest that SARS-CoV-2, through its accessory protein ORF3a, blocks Rab7 GTP-GDP cycling, which impairs lysosome fusion with other compartments and rather promotes the egress of the virus via lysosomal exocytosis.

• They said that only earth work was carried on the road and after the passage of over eight years no macadamisation or other repair work has been taken up.

• Investors are coming to similar conclusions about other macrocycle firms. The California start-up Insamo recently announced that it has secured $12 million in seed funding to develop small, orally available and cell-permeable cyclic peptides using artificial intelligence protein design expertise. The UK start-up Curve Therapeuticsjust raised about $52 million in series A funding for what it calls its “microcycle” platform.

• The California-based biotech uses its combination of AI and chemistry expertise to “address the complexities of medicinal chemistry in the macrocycle space,” the company said in a Jan. 23 release. Now, Merck has tapped up UNP to apply its tech to develop macrocyclic candidates against a “challenging” undisclosed oncology target.

• "All you ever wanted was to be a mammy and what an amazing mammy you were.

• A “realistic” obese manakin has been developed to help educate further nurses and healthcare professionals.

• The business manganate has kept his salary capped at Rs 15 crore since 2008-09 forgoing commission of nearly Rs 24 crore annually. In comparison, other directors and top executive at the company saw handsome raise in their annual salary at the financial year ending on March 31, 2018.

• Prodi, A. et al. Charge, orbital and spin ordering phenomena in the mixed valence manganite (NaMn3 3+)(Mn2 3+Mn2 4+)O12. Nat. Mater. 3, 48–52 (2004).

• Dairy milk production has increased manifold in eastern Nangarhar province this year due to growing number of dairy farms and proper feeding, Canal Project officials . . .

• The Manorial Society aims to promote the study of English history and traditions, especially the monarchy and British parliamentary institutions and the preservation of manorial records.

• Exploiting ancient manorial rights in Britain to go hunting, fishing and shooting over other people’s land, could soon be outlawed, MPs have suggested.

• In a recent report, the Commons’ All-Party Justice Select Committee called on the Government’s legal advisers to review the operation of manorial rights. The report said there were fears homeowners could be saddled with significant legal fees over disputed manorial claims, which could also delay property sales, and potentially affect house prices.

• Farmer William Brown’s attempt to register manorial rights over Aldbourne sports field and Palmers Field has met opposition from the parish council.

• Former Miami Dolphin and NFL star Vontae Davis was found dead inside a Southwest Ranches mansion on Monday, authorities said.

• We knew that marcescence had been relatively well researched in arid ecosystems, in which solar radiation strongly degrades difficult-to-decompose compounds in retained biomass. This facilitates decomposition of and nutrient release from that biomass once shed, with potential competitive advantages for the respective plants.

• Akashi, H., Okamura, E., Nishihama, R., Kohchi, T. & Hirai, M. Y. Identification and biochemical characterization of the serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase in marchantia polymorpha. Front. Plant Sci. 9 (2018).

• Ishizaki, K., Nishihama, R., Yamato, K. T. & Kohchi, T. Molecular genetic tools and techniques for marchantia polymorpha research. Plant Cell Physiol. 57, 262–270 (2016).

• Max became margrave — which Debrett's defines as the German rank of count — upon his father's death, and was instrumental in the revitalization of Lake Constance land which led to the flourishing Markgraf von Baden winery.

• The Allegheny County Police Department and county fire marshal are requesting the public's help to identify a man who could be connected to the deadly Rustic Ridge house explosion from last year.

• “In a matrilocal system we would expect to find females staying in their birthplace after their marriage and throughout their life.

• Matsuura, M. et al. A bacterial group II intron encoding reverse transcriptase, maturase and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron. Genes Dev. 11, 2910–2924 (1997).

• With the majority of votes counted, Imamoglu led by ten percentage points in the mayoral contest in Istanbul, Turkey's largest city, while his Republican People's Party (CHP) kept Ankara and won 15 other mayoral seats around the country. 

• The Conservative mayoral campaign for London had developed a nasty tone well before last week. But last Monday, it sank to a new low with an attack video that used misinformation and footage from New York to try to depict London as the “crime capital” of the world.

• Mazarinades as a Transnational Phenomenon - Many recent studies have allowed us to observe and study the mazarinade collections on an international scale anew.  Collections stored in Europe and beyond (especially in Japan, Russia and the United States) fosters new inquiry about documents printed during the Fronde. How were they distributed and disseminated abroad? What circles and networks were involved? What resonance did these texts, intended for a local audience, have outside France? How did foreign readers perceive them?

• (BATON ROUGE, La.)— Louisiana’s coastline, gamefish, and recreational angling opportunities will now receive greater protections from the industrial menhaden fishery, after the Louisiana Wildlife and Fisheries Commission approved a revised Notice of Intent (NOI) at a Special Commission Meeting today in Baton Rouge.

• At yesterday's meeting, the Wildlife and Fisheries Commission passed a Notice of Intent (NOI) to amend rules to the menhaden fishery regarding the buffer zone and spill reporting.

• Lönnerholm, G., Kreuger, A., Lindström, B., Ludvigsson, J. & Myrdal, U. Plasma and erythrocyte concentrations of mercaptopurine after oral administration in children. Pediatr. Hematol. Oncol. 3(1), 27–35 (1986).

• The ACCC has asked for new powers allowing it to stop technology giants from buying smaller startups, if the merger risks preventing a potential competitor from being created. Australia’s current merger laws require courts and regulators only consider existing competitors.

• The merger proposal has been approved by Enauta’s board of directors, and according to the company, the combination results in a balanced, five-year high organic growth portfolio with ability to add value in an environment of consolidation and resilience to commodity pricing cycles.

• Visually guided behavior begins with inputs to sensory cortices, but the decision to initiate actions engages the frontal cortex. A new study dissects a microcircuit for visual-to-motor transformation in the anterior cingulate cortex of the mouse with implications for impulsivity and disease states.

• The aforementioned groups have received 100 bicycles to be given to Community health Volunteers, Male champions and student peer educators, 100 bundles of roofing sheets to support the poultry farmers, four sets of hemocues and 10 boxes of microcuvette to be presented to the district health directorate.

• Lim, who has recently been awarded an Ernest Rutherford Fellowships by the Science and Technology Facilities Council (STFC), will therefore use this opportunity to build an apparatus that uses an array of molecules cooled to microkelvin temperatures to make an extremely precise measurement of the electron’s shape.

• Specifically, they administered salivary samples of healthy and IBD-afflicted individuals to germ-free mice respectively. After six to eight weeks, the microbial content of the mice's feces were analyzed by 16S ribosomal RNA gene sequencing, which showed that approximately 20 kinds of oral bacteria were present in these mice. Furthermore, an immunological analysis found that the level of TH1 cells, characteristically expressing interferon-gamma protein which activates microphage to enhance bactericidal activities but could be an onset of autoimmune diseases when excessive, significantly increased in some of the mice.

• A male midshipman fish, left, and a female swim in shallow Northern California waters. Their midbrain plays a key role in initiating and patterning trains of sounds used in vocal communication.

• The midbrain of the vocal Plainfin midshipman fish, sometimes called the “singing fish of California”, plays an important role in initiating and patterning the trains of sounds used in vocal communication.

• KENI have two questions for your panel. I've been a migrainer for the past 34 years having common migraine or migraine without aura. My two questions are, number one, what, speak further about prophylaxes for migraine. Verapamil was mentioned and I've been through a number of drugs. I've actually found roughly equivalent protection taking over the counter supplements, specifically massive amounts of magnesium and B2.

• Featuring a tactical-grade inertial measurement unit (IMU) and a multi-band global navigation satellite system (GNSS) receivers, the Tactical Embedded delivers milliradian attitude accuracy and centimeter-level positioning capability in a 15-gram package.

• SHOT Show 2020 – Leupold's VX-Freedom and VX-5HD riflescope lines are boosted this year by several new entries, including a staggering five fresh additions to the VX-Freedom series and a new VX-5HD variant with milliradian adjustments