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Auden Mckenzie and Actavis UK—now known as Accord-UK—will remain on the hook to pay hefty fines for their roles in introducing costly price hikes on hydrocortisone tablets.
Fierce Pharma — UK tribunal upholds £130M fine in hydrocortisone price hike case -
Postnatal steroids are used to prevent bronchopulmonary dysplasia in extremely preterm infants but may have adverse effects on brain development. We assessed connectivity metrics of major cerebral and cerebellar white matter pathways at near-term gestational age among infants who did or did not receive a standardized regimen of hydrocortisone during the first 10 days of life.
Nature — Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants | Pediatric Research -
A hydrophyte garden with a captivating hydrophyte gallery was also inaugurated to showcase around 225 hydrophyte species including 44 water lilies and lotus types. Several of the species mirror the rich biodiversity of Kanjia lake, home to over 40 hydrophyte varieties, zoo authorities said.
The New Indian Express — Odisha govt to spend Rs 17 crore on restoration of Kanjia lake in Nandankanan -
On pulmonary examination, breath sounds were absent on the right side, and a succussion splash was audible in the right upper chest when the patient was gently shaken. Chest radiography showed hydropneumothorax with a collapsed right lung and an adjacent thoracic air-liquid level, which was probably the result of repeated thoracentesis.
Hydropneumothorax in man with history of alcohol abuse associated cirrhosis -
Differential diagnosis : Pneumonia, pulmonary congestion and edema, hydrothorax and haemothorax
Manual on meat inspection for developing countries -
Our results shed light on the abundance of hydroxylamine in space and pave the way to constraining the subsequent chemistry experienced by this molecule and its derivatives in the interstellar prebiotic chemistry canvas.
Astrobiology — Processing Of Hydroxylamine, NH2OH, An Important Prebiotic Precursor, On Interstellar Ices - Astrobiology -
Albion Resources noted visible galena (the principal ore of lead) and hydrozincite (a white mineral containing zinc) 350m north of a historical drill hole within the Lennard Shelf zinc-lead project.
Small Caps — Albion Resources reports visible zinc-lead at Lennard Shelf project -
Sur un secteur du prêt-à-porter féminin hyperconcurrentiel et impacté par la crise, les frères Brin ont trouvé grâce à leurs boxes de vêtements pour femmes la recette du succès de Clic and Fit.
Métropole de Lyon. Avec Clic and Fit, les frères Brin, rois des boxes de vêtements pour femmes -
After gathering results by running the process many times in sequence or parallel, the researchers construct a hypersurface where one axis represents the result of a measurement and the other two (or more) axes represent different noise parameters. This hypersurface yields an estimate of the noise-free observable and gives information about the effect of each noise rate.
Argonne researchers develop new method to reduce quantum noise | Argonne National Laboratory -
About a decade ago, Adams’ research began shifting to also address evolutionary and applied questions. For the basic research, he began a new line of inquiry with his model hyperthermophile microbe Pyrococcus furiosus—“furious” or “rushing fireball”—which he has been working with since it was discovered in 1986 in hot sea vents.
UGA Research News — Mike Adams: A chemistry with biology - UGA Research News -
Ohshima, T. Structural characteristics of active and inactive glutamate dehydrogenases from the hyperthermophile Pyrobaculum islandicum. Biosci. Biotechnol. Biochem. 76, 1601–1610 (2012).
Nature — Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase | Communications Biology -
Inhaler une solution saline hypertonique peut aider les bébés atteints de mucoviscidose (fibrose kystique) à mieux respirer, conclut cette équipe l'Université de Heidelberg, après suivi de 40 nourrissons atteints. Des données précieuses présentées dans l’American Journal of Respiratory and Critical Care Medicine (AJRCCM) qui confirment à un an, chez les bébés traités, un meilleur indice de clairance pulmonaire, une prise de poids plus importante ainsi qu’une croissance (en taille) plus élevée.
santé log — MUCOVISCIDOSE chez le nourrisson : Les bénéfices d’une solution saline hypertonique | santé log -
Tang, Z., Ding, X.-L., Liu, Y., Zhao, Z.-M. & Zhao, B.-X. A new probe based on rhodamine B and benzothiazole hydrazine for sensing hypochlorite in living cells and real water samples. RSC Adv. 5, 99664–99668 (2015).
Nature — Novel probe based on rhodamine B and quinoline as a naked-eye colorimetric probe for dual detection of nickel and hypochlorite ions | Scientific Reports -
Proprietary electroless nickel baths, which have been marketed in concentrated form for about 20 years, contain combinations of complexing agents, buffers, and stabilizers. The baths are the result of much empirical research and development. The technical data sheets of suppliers disclose only the nickel and hypophosphite content. Few new formulations have been published; Gutzeit's 1959 articles7 on bath chemistry are still the best source of information. Numerous patents claiming improvements in baths or deposits have been granted. Most of these disclose various stabilizers or additives.
The Formulation of Electroless Nickel-Phosphorus Plating Baths | Products Finishing -
On physical exam, the 72-year-old woman retained visual acuity of light perception, and the exam was otherwise notable for "a hypopyon filling the anterior chamber with an epithelial defect involving most of the cornea," while the right eye was unremarkable (she had bilateral dry eye syndrome).
Case Reports Detail Vision Loss Linked to Recalled Artificial Tears | MedPage Today -
The AM graft was prepared and cryopreserved by local eye bank using the Good Tissue Banking Practice procedures. Despite the tested sterility of the ocular surface, the preoperative antibiotic treatment, and the uneventful perioperative period, he developed a 2 mm hypopyon within 48 hours when reviewed him after primary AMT. He was using the routine regimen of tobramycin 3 mg/ml and dexamethasone 1 mg/ml eye drops six times daily on a fixed combination.
Primary Amniotic Membrane Transplantation for Sterile Corneal Ulcer leading to hypopyon: Rare case -
Researchers have identified a genetic mutation that may be responsible for a rare and deadly condition—central congenital hypoventilation syndrome (CCHS)—characterized by inadequate breathing during sleep, which, in its classic form, usually begins in newborns shortly after birth.
Sleep Review — Genetic Culprit in Sleep-Related Breathing Disorder in Newborns | Sleep Review -
Cardiomyopathy and respiratory insufficiency, which results in alveolar hypoventilation and hypercapnia, are responsible for much of the mortality and morbidity in patients with muscular dystrophy.1 And the repeated instances of hypoxia and reoxygenation involved in sleep apnea increase the risk of cardiovascular and cerebrovascular diseases.2
In Muscular Dystrophy, the Importance of Characterizing Hypoventilation and Sleep Apnea - Duchenne Muscular Dystrophy -
HONOLULU (AP) — A man accused of physically assaulting a woman at a U.S. research station in Antarctica was then sent to a remote icefield where he was tasked with protecting the safety of a professor and three young graduate students, and he remained there for a full week after a warrant for his arrest was issued, documents obtained by The Associated Press show.
Yahoo News — Man accused of Antarctic assault was then sent to remote icefield with young graduate students -
The country instructed that imams and muezzins should arrange for iftar to take place at an "appropriate place " in the courtyards of the mosques, prohibiting the creation of temporary rooms or tents for this purpose.
WION — Saudi Arabia bans Iftar meals inside mosques during holy month of Ramadan, says Imams & muezzins should... - World News -
Fedele, F., Giaccio, B., Isala, R. & Orsi, G. The Campanian ignimbrite eruption, Heinrich event 4, and Palaeolithic change in Europe: a high-resolution investigation. In Volcanism and the Earth’s Atmosphere 139, (American Geophysical Union, 2003).
Nature — Reconstructing the plinian and co-ignimbrite sources of large volcanic eruptions: A novel approach for the Campanian Ignimbrite | Scientific Reports -
Collection galleries throughout NMWA’s building present a joyful and provocative combination of works spanning six continents and six centuries that emphasizes the illimitable vision of women artists worldwide through themes:
Remix: The Collection | Exhibitions | MutualArt -
When it comes to jazz, Carrington digs deep into its intertwining legacies and reaches not for higher ground but for the illimitable heavens.
DownBeat Magazine — Review: Terri Lyne Carrington’s Montreal Jazz Fest Invitation Series -
Quand va véritablement débuter le prochain bull run du Bitcoin ? Une question dans tous les esprits alors que le marché des cryptomonnaies tente de se relever des attaques réglementaires de la Securities and Exchange Commission (SEC) des États-Unis. Mais cela ne concerne visiblement pas le BTC, en train de poursuivre sa pression haussière contre une résistance fatidique des 31 000$ qui lui barre toujours la route. Et alors que certains se demandent à quel moment entrer dans cette course, d’autres sont déjà dans les starting-blocks avec une supply devenue illiquide à plus de 78%.
CryptoActu — Bitcoin - Plus de 78% de sa supply est actuellement illiquide - CryptoActu -
Players engage in daily quests and challenges while exploring the Illuvium landscape, fighting Illuvials and other players, and following the shared plot. They gather illuvial along the way, which have a variety of traits that make them variable in rarity, utility, and desirability. These consist of:
CoinGape — Illuvium Game: A beginner's Guide To The Trending Web 3 Game -
Mnangagwa said Karo Mining’s ‘master plan’ earmarked the building of infrastructure on a significant portion of this area and that to avoid the sterilisation of the mineral resources, Karo had undertaken “.. the mining of these illuvial deposits which will be value added into the production of ferrochrome and or other chrome-based products”.
Miningmx — Chrome mine in Karo Mining 'master plan' due by October - Miningmx -
Analysis of moisture imbibition through the hydrophilic, untreated porous ceramic material: (a) through (f) experimental results; (g) through (l) corresponding 2D simulation results; and (m) through (y) the visualization of moisture infusion into a 3D ceramic block for 6-time steps (t6 > t5 > t4 > t3 > t2 > t1).
Nature — From superhydrophilicity to superhydrophobicity: high-resolution neutron imaging and modeling of water imbibition through porous surfaces treated with engineered nano-coatings | Scientific Reports -
Soós, B., Janovics, K., Tóth, Á., Di Nardo, M. D. & Szalma, J. Association between third molar impaction status and angle or condylar fractures of the mandible: a retrospective analysis. J. Oral Maxillofac. Surg. 78(7), 1162.e1-1162.e8 (2020).
Nature — The influence of wisdom tooth impaction and occlusal support on mandibular angle and condyle fractures | Scientific Reports -
KUALA LUMPUR (Feb 23): Genting Bhd’s net loss widened to RM168.72 million in the fourth quarter ended Dec 31, 2022 (4QFY2022) from RM129.8 million a year earlier, mainly due to net impairement loss of RM304.8 million besides higher depreciation charges and net unrealised foreign exchange losses.
The Edge Malaysia — Genting incurs RM304.8 mil impairment in 4Q; declares nine sen dividend -
Some roads along the South Shore were left impassable when fierce waves produced by the nor’easter crashed ashore and caused flooding during high tide on Tuesday afternoon.
Yahoo News — South Shore roads impassable as nor’easter brings fierce waves, flooding during high tide -
WINSTON COUNTY, Ala. (WBRC) - All county roads and bridges in Winston County are considered impassable to the public until further notice.
https://www.wbrc.com — County roads, bridges in Winston County impassable until further notice -
This comes on the back of concerns raised by the Ghana National Association of Cocoa Farmers about the health complications of some of its members, alleging that some of them are suffering from blindness and impotence due to the prolonged usage of agrochemicals.
Citinewsroom - Comprehensive News in Ghana — None of our contracted mass sprayers suffers impotence, blindness - COCOBOD -
Mission: Impossible – Dead Reckoning Part One will be coming to cinemas on July 14, 2023. Ahead of its release, Cruise shared an impressible behind-the-scenes look at a dangerous stunt involving a cliff and a motorcycle.
Yahoo Finance — Tom Cruise is channeling Maverick in reported Mission: Impossible 8 stunt -
After a hearty breakfast at the galley shed the squad and the galley, steered and towed by impressible festival veterans John Hunter and Brian Hunter, toured the isle.
The Shetland Times — Super night for Uyeasound festival | The Shetland Times Ltd -
However, inactivation and mutations in TP53 have also been associated with post-MPN acute myeloid leukemia (AML) transformation (in 25%-50% of cases) [10,11,12,13], suggesting that inactivation of the TP53 tumor suppressor could be a cooperating contributing event in combination with signaling due to JAK2 gain-of-function mutation during the transformation process.
Nature — Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms | Blood Cancer Journal -
The All-Star took an inadvertant Boris Diaw finger to the right eye during a scrimmage on Wednesday night, and returned to Phoenix Thursday morning to be evaluated by Dr. Jay Schwartz.
Stoudemire Lucky Eye Injury Not Worse | NBA.com -
It’s a hard trick to pull off, mining a child’s eye view of an adult situation for pathos, and inadvertant humour. Lee Hall’s Spoonface Steinberg, the protagonist what started out as a 1997 Radio 4 play, is a doubly, triply naïve narrator. Seven years old, autistic, cloistered away from the world by cancer, she tells her own story from a hospital ward.
Exeunt Magazine — Spoonface Steinberg - Exeunt Magazine -
“In one of the most inane moves we have ever seen, GameStop’s Board of Directors delegated authority to manage the company’s portfolio of securities to its CEO and has extended the investment policy’s range to include equities,” Wedbush analyst Michael Pachter said in a note released Thursday. “Investors have a myriad of investment vehicles available to them and therefore do not need GameStop to act as a mutual fund.”
MarketWatch — GameStop’s new investment policy ‘alarming’ and ‘inane,’ says Wedbush - MarketWatch -
GameStop’s decision to focus on buying other stocks shouldn’t inspire confidence in the company’s ability to get the core business back on track. Wedbush analyst Michael Pachter, who dubbed the new investment strategy as “the most inane decision” he has ever seen, said in a report that investors “do not need GameStop to act as a mutual fund.” Pachter noted that the company “should use its excess cash to buy back stock,” adding that the move by GameStop and Cohen was “alarming.”
InvestorPlace — Ryan Cohen’s ‘Inane’ Move Is Bad News for GME Stock | InvestorPlace -
"Of all the subspecies of reindeer found in the high north, the Svalbard reindeer has the most inbreeding and the lowest genetic diversity," says Nicolas Dussex, a postdoc at Norwegian University of Science and Technology´s (NTNU) Department of Natural History.
EurekAlert! — Inbreeding can be beneficial in the long run | EurekAlert! -
Excessive inbreeding increases the probability of uncovering homozygous recessive genotypes and has been associated with an increased risk of retained placenta and lower semen quality in horses. No genomic analysis has investigated the association between inbreeding and pregnancy loss. This observational case-control study compared genetic inbreeding coefficients (F) of naturally occurring Thoroughbred early pregnancy loss, mid- and late-term pregnancy loss, and controls.
EquiManagement — Does Inbreeding Contribute to Pregnancy Loss in Thoroughbreds? - EquiManagement -
The Svalbard reindeer, among all reindeer subspecies, stands out for its high level of inbreeding and notably low genetic diversity.
Earth.com — Inbreeding can actually be beneficial for some species in the long run • Earth.com