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• Meanwhile, they will operate from the WISH shop at 4 The Parade, Kidlington, on Fridays and Saturdays, offering the larder and a less extensive climatarian kitchen service.

• The Secretary-General’s appeal for a lasting peace and a humanitarian ceasefire to enable the effective delivery of food, fuel and medicines came as the UN agency for Palestinian refugees, UNRWA, confirmed that it had been barred by the Israeli authorities from transporting assistance to northern Gaza.

• Eurasia was especially hit harder with longer lasting heat waves, the study said. Heat waves slowed down most in Africa, while North America and Australia saw the biggest increases in overall magnitude, which measures temperature and area, according to the study.

• “After almost six months, … the vote, almost unanimous,” has demanded a lasting and immediate ceasefire in Gaza.

• The thief (or thieves) had seized the works from the gallery walls at night and removed the fragile watercolours from their frames. They were then rolled up in a cardboard tube, with the Van Gogh protruding out of one end. The tube was later abandoned, by being lent against the closed lavatory building, beside sodden leaves and litter. It had been a rainy day and a police statement described the weather as “extremely bad”.

• Eliav, E., Kaldor, U. & Ishikawa, Y. Transition energies of ytterbium, lutetium, and lawrencium by the relativistic coupled-cluster method. Phys. Rev. A 52, 291–296 (1995)

• Schmidt, M. W. & Poli, S. The stability of lawsonite and zoisite at high pressures: experiments in CASH to 92 kbar and implications for the presence of hydrous phases in subducted lithosphere. Earth Planet. Sci. Lett. 124, 105–118 (1994)

• Paola Manzotti, Michel Ballèvre, Pavel Pitra and Federica Schiavi, 2021. Missing lawsonite and aragonite found: P–T and fluid composition in meta-marls from the Combin Zone (Western Alps). Contributions to Mineral and Petrology: 176, 60. https://doi.org/10.1007/s00410-021-01818-0

• "All patients who suffer from suspicious symptoms are examined by a military dermatologist, receive appropriate treatment and are referred to a dedicated leishmania clinic as needed,” he added.

• Mandell, M. A. & Beverley, S. M. Concomitant immunity induced by persistent leishmania major does not preclude secondary re-infection: implications for genetic exchange, diversity and vaccination. PLoS Negl. Trop. Dis. 10, e0004811 (2016).

• Hajjaran, H. et al. Detection and molecular identification of leishmania RNA virus (LRV) in Iranian Leishmania species. Arch. Virol. 161, 3385–3390 (2016).

• These porcelains or ceramics are generally reinforced with leucite. Multiple firings will increase leucite content and the CTE. So really we only have a few attempts to get it right.

• Cette différence s'explique par le type de leuconychie (« Leukonychia and Other Nail Discoloration: An Overview », publié dans la revue Syndromes : Rapid Recognition and Perioperative Implications en 2019). En effet, il peut s'agir d'une leuconychie véritable : dans ce cas-là, les taches blanches prennent naissance dans la matrice de l'ongle. En revanche, en cas de leuconychie apparente, les taches blanches ne sont pas dans l'ongle, mais au niveau du lit de l'ongle, la partie de l'ongle qui se trouve sous l'ongle. En termes de classification, les médecins répertorient quatre types de leuconychies véritables :

• They also supplied some 750,000 bottles of phenacyl chloride inhibitors to treat poisoning with mustard gas, lewisite and hydrocyanic acid derivatives.

• While not wavering in its belief that there was not full-scale lewisite production in Willoughby, the Corps last month included $100,000 in its current budget for an archived photographic analysis and historical site assessment of the location this year.

• A jury in New York found former NRA gun lobby chief Wayne LaPierre liable on Friday, February 23, for corruptly mismanaging the organization, US media reported. Lapierre and a senior executive of the National Rifle Association must pay a penalty of $6.35 million "for years of corruption and greed," said state Attorney General Letitia James.

• HeLa cells, displaying a functional cGAS–STING pathway, were used for most of the experiments. U2OS cells, expressing cGAS, were used to independently validate hits obtained from the siRNA screen. HEK293T cells were used for immunoprecipitation and ubiquitylation studies using transiently expressed tagged constructs. BJ-5ta cells, THP-1 cells and primary endothelial cells were used to ascertain the relevance of cGAS nuclear degradation by the CRL5–SPSB3 ubiquitin ligase across distinct cell types and primary human cells. Cell lines were repeatedly tested for mycoplasma by PCR. No method of cell line authentication was used.

• a Distribution of the number of categories of ligands identified for each E3 ligase from multiple data sources. b Chord chart for E3 ligases with 3 types of ligands. c Circular barplot representing the distribution of unique ligands of E3 ligases. d E3 ligases with top number of unique ligands and one dot representing 1000 ligands. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were explored in PROTAC experiment.

• Text description provided by the architects. The clients came to us at a pivotal stage in their lives as soon-to-be empty nesters. The evolving needs of a family became the impetus for how we imagined a house that could embody the state of transition at a conceptual and experiential level. We chose the word liminal to encapsulate ideas that have informed the design process: namely the feeling of inhabiting a transitory place; orchestrating movement through space, and dwelling in the moments between from and to...

• Through the fourth amendment to the Patent Law of China in 2020, China established its own pharmaceutical patent linkage system. In December 2021, the Beijing Intellectual Property Court accepted the first pharmaceutical patent linkage lawsuit and issued its decision on April 15, 2022. This presentation will discuss China’s new pharmaceutical patent linkage system, including the legislative process and its current operation in practice. Topics will cover: 

• Direct and relayed links are eligible for use in Eurosystem credit operations if they comply with the eligibility criteria.

• "As a result of work with the detained terrorists, examination of the technical devices seized from them and analysis of information on financial transactions, evidence of their links with Ukrainian nationalists has been obtained," Russia's Investigative Committee said on Thursday.

• The label for irinotecan liposome comes with a boxed warning, noting a risk for severe or life-threatening neutropenia and diarrhea.

• Targeted Drug Delivery System using Acoustic Lens-attached US (LENS) and Sonoresponsive Liposomes. Schematic of the target-specific drug delivery system by acoustic lens-attached US system (LENS) with the antitumor drug-loaded sonoresponsive liposome carrier (IMP301). Upon reaching the target tumor region through the microvasculature, disrupted IMP301 releases an antitumor drug by FUS exposure and MB oscillation.

• The excavation and subsequent research, which was led by Pre-Construct Archaeology (PCA) and involved archaeologists from Newcastle University, revealed a rectangular building which would have been built from timber and divided internally by three aisles. This type of multi-function "aisled" building was fairly common in Roman Britain and would have been used both as a house and place for crafts. However, although the archaeologists found evidence of small-scale metalworking at one end of the building, it was not at a level that would have produced the amount of litharge discovered.

• Archaeologists found a huge amount of litharge - a lead oxide and by-product of silver extraction - which suggests a clan was melting down metal to get at its precious material.

• Aubrite falls in rare achondrite group of meteorites. Aubrites have sulphides of sodium, titanium, manganese, chromium and calcium. These are all lithophile elements.

• A High Court judge has made a recommendation to the attorney general that a struck off solicitor be declared a vexatious litigant following almost two decades of litigation against the Law Society and the Solicitors Regulation Authority.

• Hiab, part of Cargotec, has received a large order of EUR 5 million for loader cranes to be used in offshore wind turbines. The order was booked in Cargotec’s Q1 2024 orders received and will be delivered during 2024.  

• The 275 hp (205 kW) crawler loader has an operating weight of 65,901 lb (29 892 kg) and replaces the 973K worldwide. It joins the 953 (160 hp/119 kW) and 963 (202 hp/151 kW) in the Cat track loader line.

• GWINNETT COUNTY, Ga. — Sometimes you fight fire with fire, and sometimes you must fight a front-end loader with another front-end loader.

• Once the 3D images had been processed, the volume of each segmented lobule was defined by computing the total number of voxels of the watershed mask, which was translated into a physical volume. The contact surface between each pair of segmented lobules was also computed as the voxels having a distinct label from their neighbours and whose labels corresponded to those of the pair of lobules considered.

• At present, means till March 31, 2024, nodal offices across central and state governments, in addition to pension-related autonomous bodies, will have to use password-based login mechanisms for NPS transactions. However, users will be required to undergo Aadhaar-based login authentication from April 1.

• In coordination with the AONL Foundation and Joslin Insight, five longitudinal studies have been conducted since 2020. The collective data are a fascinating avenue into the hearts and minds of nursing leaders and how they perceive the healthcare industry and nurses’ places in it.

• • Clarification of, and the provision of additional details on, louver core-area measurement.

• The concept draws from the notion of ‘learning from nature’, not only involving imitation but also embracing natural light as a guide, capturing the nuances of light and shadow and reinterpreting nature in a simple and organic manner. The ever-changing surface, informed by the play of light gradually unfolds during the day. The louver shadows silently record the passage of time, as the building cleverly utilizes natural light to reproduce the vibrant essence of the Fuchun landscape.

• In the case of reinvesting investment funds and investment funds with very low distributions, investors are supposed to pay tax on a notional minimum income each year, the so-called advance lump sum. This usually happens on the first working day of the new calendar year - usually 2 January.

• Two years ago, Wayward head brewer Shaun marked the birth of his son Austin by brewing Wayward Son, a West Coast IPA bursting at the seams with lupulin hop powder. Of course, an IPA isn’t the kind of beer you cellar away to revisit each year in celebration, so instead Wayward returns to brewing fresh batches of the celebratory beer. But, just as Shaun’s son has grown and changed (I assume), so has Wayward Son - it’s juicy and hazy as all get-out.

• a, DMSP and DMSOP lyase activities from model organisms with known DMSP lyases. The complement of ddd genes found in tested bacteria are indicated in parentheses. b, DMSP and DMSOP lyase activities of Ddd and Alma enzymes expressed in E. coli BL21. Data are presented as mean ± s.d. (n = 3).

• The ratios of released reducing sugars were found to be: alginate lyase versus three-enzyme mixture = 101.3%; alginate lyase versus laminarinase = 136.6%, and alginate lyase versus fucosidase = 1242%. Regarding the above values, the alginate lyase ID 22 was selected as the most active enzyme for the degradation of L. digitata cell wall.

• Researchers from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (LSB) have identified the odorants responsible for the characteristic lychee note of Muscaris grapes. The white Muscaris grape variety was bred in 1987 by the Freiburg State Viticulture Institute and combines the excellent fungal resistance of the Solaris variety with the intense aroma of the Yellow Muscat.

• In their quest to unravel this mystery, the researchers analyzed the genomes of two lycophyte species: Huperzia asiatica and Diphasiastrum complanatum.